Substructure Enrichment Report

Mapping Details for your submission help

# Active Inactive
Your Submission 607 231460

Table 1. Substructure Enrichment help

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# Substructure Odds Ratio p-value kA Active kB InActive
1 N(=CNC(=O)C)C(=CS)C 5.83 2.53e-08 22 611 1429 231460
2 C(=NC(=C)C)(NC(=O)C)S 5.66 1.71e-08 23 611 1538 231460
3 C(=O)(C(=O)O)O 5.38 1.87e-08 24 611 1687 231460
4 c1(scc(n1)C)NC 5.11 7.12e-10 29 611 2148 231460
5 c1(scc(n1)C)NCC 4.97 9.75e-08 24 611 1828 231460

Table 2. Substructure Enrichment help

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# Substructure Odds Ratio p-value kA Active kB InActive
1 c1(ccccc1)C(=C)N AND C(SC=C)NC(=O)C 14 7.41e-10 18 611 487 231460
2 c1(ccccc1)C(=C)N AND C(SC=C)NC=O 13.97 1.33e-10 19 611 515 231460
3 c1(ccccc1)CN=C AND C(=NC=C)(NC(=O)C)S 13.85 8.86e-10 18 611 492 231460
4 c1(ccccc1)C=CS AND C(SC=CN)NC(=O)C 13.55 7.23e-09 17 611 475 231460
5 c1(ccccc1)C(=C)N AND S(CNC=O)C=CC 13.37 1.65e-09 18 611 510 231460

Table 3. Substructure Enrichment help

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# Substructure Odds Ratio p-value kA Active kB InActive
1 c1(ccccc1)C(=C)N AND C(SC=C)NC=O AND C(=N)(SC)NCC 14.59 4.68e-08 19 611 493 231460
2 c1(ccccc1)C=CS AND c1(sccn1)NC AND C(=O)(NC)C 14.38 1.77e-09 21 611 553 231460
3 c1(ccccc1)CN=C AND C(=NC=C)(NC(=O)C)S AND c1(ccccc1)C=CS 14.29 4.03e-07 18 611 477 231460
4 c1(ccccc1)C(=C)N AND C(SC=C)NC(=O)C AND c1(ccccc1)C=CS 14.23 4.33e-07 18 611 479 231460
5 c1(ccccc1)C(=C)N AND S(CNC=O)C=CC AND C(=N)(SC)NCC 13.97 6.00e-07 18 611 488 231460