Target/Pathway Enrichment Report

Mapping Details for your submissionhelp

# Active Inactive
Your Submission 2041 136690
Mapped to Target 2051 136690
Mapped to Reactome 2051 136690
Mapped to GO 2051 136690

Table 1. Target/MultiTarget Enrichment help

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# TARGET/MULTI-TARGET Odds Ratio p-value kA size
Active
kB size
InActive
1 gene: MITF inhibitor (gi:40807040, assay: 493191)
139.52 1.27e-119 84 2051 36 122639
2 gene: S1PR4 antagonist (gi:15929025, assay: 1524)
108.15 4.18e-168 123 2051 68 122639
3 gene: S1PR1 agonist (gi:13027636, 9 assays integrated)
97.16 3.01e-104 78 2051 48 122639
4 gene: MITF inhibitor (gi:40807040, assay: 493240)
94.79 2.06e-86 65 2051 41 122639
5 interaction (assay:504601 ) inhibitor
gene: MDM4 gi:88702791
gene: MDM2 gi:89993689

94.72 7.87e-214 160 2051 101 122639

Table 2. Pathway Enrichment help

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# GO Term Odds Ratio p-value kA size
Active
kB size
InActive
1 (activator) Regulation of HSF1-mediated heat shock response 55.74 4.05e-31 27 1999 22 90800
2 (activator) Cellular response to heat stress 55.74 4.05e-31 27 1999 22 90800
3 (activator) Regulation of mRNA stability by proteins that bind AU-rich elements 50.87 1.61e-31 28 1999 25 90800
4 (inhibitor) BMAL1:CLOCK,NPAS2 activates circadian gene expression 28.09 3.21e-270 282 1999 456 90800
5 (inhibitor) NOTCH1 Intracellular Domain Regulates Transcription 19.93 2.72e-248 294 1999 670 90800

Table 3. GO term Enrichment help

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# GO Term Odds Ratio p-value kA size
Active
kB size
InActive
1 (inhibitor) camera-type eye development 59.38 3.83e-96 528 2014 441 99895
2 (inhibitor) neural crest cell migration 55.9 0. 266 2014 236 99895
3 (inhibitor) positive regulation of neuroblast proliferation 55.66 0. 266 2014 237 99895
4 (inhibitor) cartilage development 55.15 0. 268 2014 241 99895
5 (inhibitor) nuclear hormone receptor binding 54.05 0. 267 2014 245 99895